Ingredients
What's Inside Lipera?
Each ingredient was selected to support different aspects associated with lipedema—including fluid movement and balance, microcirculation, adipose tissue function, vascular integrity, and inflammatory signaling. When combined in carefully considered dosages, they create a comprehensive system of support for women navigating lipedema.
Below is a complete breakdown of every ingredient in Lipera, why each one matters, and how they work together to support the body systems involved in lipedema.
Diosmin (800mg)
Diosmin is one of the most studied compounds for leg health, circulation, and lymphatic function. Research suggests that diosmin supports microvascular integrity, tissue composition, and a balanced inflammatory response, while contributing to overall leg comfort over time.
Its role in vascular function makes it a valuable ingredient for women navigating lipedema who experience swelling, pressure, or soreness.
Diosmin’s benefits have been documented in a clinical study, showing its ability to support healthier fluid movement and daily discomfort.
Vitamin D (2,000iu)
Vitamin D plays an important role in immune regulation, inflammation balance, and muscular function. As this clinical analysis shows, many women with lipedema have low vitamin D levels, highlighting its importance in overall tissue comfort and energy levels. Maintaining adequate vitamin D levels supports the body’s natural processes involved in inflammatory balance and everyday function.
Resveratrol (200mg)
Resveratrol supports a balanced inflammatory response, antioxidant protection, and healthy microcirculation, as explored in clinical research. Many women navigating lipedema experience oxidative stress in the tissue, and resveratrol plays a role in supporting a more balanced cellular environment, as seen in this medical trial. This may contribute to a less reactive and more stable feeling in the legs over time.
Coenzyme Q10 (60mg)
CoQ10 plays a key role in cellular energy production and supports microvascular health. Many women navigating lipedema experience fatigue and slower recovery, and CoQ10 helps support overall tissue resilience and comfort.
Curcumin (175mg)
Curcumin has been widely studied for its role in inflammatory signaling, oxidative balance, and vascular function, including pathways such as NF-κB. Research suggests it supports endothelial function and overall lymphatic activity. These effects are relevant for women navigating lipedema and lymphedema, where inflammatory balance and fluid dynamics play an important role in overall tissue comfort, as seen in this clinical summary.
Vitamin C (500mg)
Vitamin C plays an important role in capillary integrity, antioxidant protection, and collagen formation. These functions are relevant for vascular and tissue health, including factors associated with lipedema. Clinical research has explored its role in supporting microvascular function and oxidative balance, which may contribute to overall tissue comfort and fluid balance.
Cleavers (20mg)
Cleavers herb is traditionally used to support lymphatic function and healthy fluid movement within tissues. This may contribute to a reduction in feelings of swelling, heaviness, and tenderness commonly experienced in lipedema.
Dandelion Root (5mg)
Dandelion root is traditionally used to support fluid balance and the body’s natural elimination processes. This may contribute to a reduction in feelings of swelling, heaviness, and discomfort often associated with lipedema.
Calendula Flower (5mg)
Calendula flower is traditionally used to support a balanced inflammatory response and vascular function, contributing to overall tissue comfort. This may help ease feelings of tenderness, swelling, and skin sensitivity often experienced with lipedema.
Hesperidin (100mg)
Hesperidin is another compound that works synergistically with diosmin. Together they help stabilize capillary walls, promote tissue repair, and improve lymphatic performance. This occurs by inhibiting pathways like NF-κB and reducing certain cytokines, Its effects complement diosmin and are supported by modern research, including findings in a vascular clinical analysis.
Butcher's Broom (150mg)
Butcher’s broom is traditionally used to support healthy fluid balance and venous tone, which may help ease feelings of heaviness and swelling in the legs. Women navigating lipedema often describe stiffness or pressure that worsens throughout the day, and butcher’s broom helps support vascular responsiveness and overall tissue comfort.
Its role has been explored in clinical research involving women with lipedema, with findings suggesting support for comfort and inflammatory balance.
Selenium (200mcg)
Selenium is a powerful antioxidant mineral that supports tissue resilience and a balanced inflammatory response. Lipedema tissue can be sensitive to inflammatory triggers, and selenium plays a role in helping maintain this balance at the cellular level. Its effects have been explored in this clinical review involving lipedema, including a review highlighting selenium’s role in supporting oxidative balance—an important factor in tissue health.
Bromelain (200mg)
Bromelain is an enzyme extracted from pineapple that supports a balanced inflammatory response, tissue comfort, and healthy fluid dynamics. Many women report feeling less tightness and more ease in movement after incorporating bromelain into their routine. Its role has been explored in this clinical enzyme review, with findings suggesting its involvement in inflammatory pathways and overall tissue response.
Rutin (80mg)
Quercetin (230mg)
Quercetin is a natural antioxidant that supports a balanced inflammatory response and tissue stability. Women navigating lipedema often describe flare-ups triggered by stress or hormonal changes, and quercetin plays a role in supporting the body’s response to these shifts. It also supports microcirculation and has been widely studied in vascular health, including in clinical analyses exploring its role in endothelial and inflammatory pathways, as seen in this clinical analysis.
Magnesium Glycinate (200mg)
Magnesium plays a role in muscle function, nerve signaling, and tissue integrity. Many women navigating lipedema describe nighttime cramping, restless legs, or tension that can add to overall discomfort. Clinical research has explored magnesium’s role in supporting smooth muscle function, which may contribute to a more balanced and stable feeling in the legs.
NMN (200mg)
NMN (Nicotinamide Mononucleotide) is a naturally occurring compound your body uses to produce NAD⁺, a molecule involved in cellular energy, metabolism, DNA repair, and healthy aging. For women navigating lipedema, supporting NAD⁺ production helps maintain cellular efficiency, vascular function, and tissue resilience—factors associated with inflammatory balance, energy levels, and overall system stress.
Rutin is a natural bioflavonoid known for supporting capillary strength, vascular flexibility, and antioxidant activity. Clinical research has explored its role in capillary function, with findings suggesting support for the integrity of small blood vessels.