Ingredients
What's Inside Lipera?
Each ingredient was chosen to support a different part of the lipedema pathway—fluid movement and regulation, microcirculation, adipose tissue composition, vascular integrity and inflammatory signaling. When combined in the proper dosages, they create a comprehensive system of support for women with lipedema.
Below is a complete breakdown of every ingredient in Lipera, why each one matters, and how they work together to fight lipedema.
Diosmin
Diosmin is one of the most researched compounds for leg health, circulation, and lymphatic flow. Studies demonstrate that diosmin supports microvascular integrity, tissue composition, reduces inflammatory markers and even improves leg comfort over time.
It's effect on vascular composition makes it a valuable ingredient for women with lipedema who experience swelling, pressure, or soreness.
Diosmin’s benefits have been documented in a vascular study, showing its ability to support healthier fluid movement and reduce daily discomfort.
Curcumin
Curcumin inhibits NF-κB and inflammatory cytokines, reduces oxidative stress, improves endothelial function, and supports lymphatic pumping—lowering pain, swelling, and tissue inflammation in lipedema.
Vitamin C
Vitamin C supports lipedema by strengthening capillaries, reducing vessel leakiness, lowering oxidative stress, and aiding collagen formation. This helps limit fluid leakage into tissue, decrease swelling and bruising, and support healthier lymphatic and vascular function.
Hesperidin
Hesperidin is another compound that works synergistically with diosmin. Together they help stabilize capillary walls, promote tissue repair, and improve lymphatic performance. This occurs by inhibiting pathways like NF-κB and reducing certain cytokines, Its effects complement diosmin and are supported by modern research, including findings in a vascular analysis.
Butcher's Broom
Butcher’s broom helps decrease fluid retention and supports venous tone, which can reduce feelings of heaviness and swelling in the legs. Women with lipedema often describe stiffness or pressure that worsens through the day, and butcher’s broom directly supports those symptoms by improving vessel responsiveness and tissue comfort.
Its benefits were documented in a retrospective clinical review, which showed improvements in discomfort and inflammatory symptoms among women with lipedema.
Selenium
Selenium is a powerful antioxidant mineral that supports tissue resilience and inflammation balance. Lipedema tissue reacts strongly to inflammatory triggers, and selenium helps moderate those reactions so the tissue becomes less sensitive. A tissue metabolic evaluation showed selenium’s role in supporting oxidative balance, which is particularly relevant for lipedema where oxidative stress can worsen symptoms.
Bromelain
Bromelain is an enzyme extracted from pineapple that supports inflammation control, tissue comfort, and swelling reduction. Many women report reduced tightness and more comfortable movement soon after incorporating bromelain. Research discussed in a clinical enzyme review supports its ability to reduce inflammatory activity and improve tissue response.
Rutin
Vitamin D
Vitamin D plays an important role in immune regulation, inflammation balance, and muscular function. Many women with lipedema are found to be low in vitamin D, which can impact tissue comfort and overall energy. Adequate vitamin D levels support the body’s ability to manage inflammatory triggers that can intensify lipedema symptoms.
Quercetin
Quercetin is a natural antioxidant that supports inflammation balance and tissue stability. Women with lipedema often describe sudden flare-ups triggered by stress or hormonal changes, and quercetin helps calm those biological reactions.It also supports microcirculation and has been widely studied for vascular health.
Magnesium
Magnesium helps relax muscles, calm nerve irritability, and support tissue repair. Many women with lipedema experience nighttime cramping, restless legs, or tension that worsens discomfort. Magnesium supports smoother muscle function, making the legs feel less reactive and more stable.
NMN
NMN (Nicotinamide Mononucleotide) is a naturally occurring compound your body uses to produce NAD⁺, a molecule essential for cellular energy, metabolism, DNA repair, and healthy aging. For women with lipedema, supporting NAD⁺ production helps improve cellular efficiency, vascular health, and tissue resilience, which are essential for reducing inflammation, fatigue, and systemic stress.
Resveratrol
Resveratrol supports inflammation balance, antioxidant protection, and healthier microcirculation. Many women with lipedema experience oxidative stress in the tissue, and resveratrol helps calm that environment so your legs feel less reactive and more stable.
Rutin is a natural bioflavonoid known for supporting capillary strength, vascular flexibility, and antioxidant activity. It plays a role in stabilizing small blood vessels, which is helpful for women with lipedema who experience microvascular fragility and frequent bruising.
Coenzyme Q10
CoQ10 boosts cellular energy and supports microvascular health. Many women with lipedema experience fatigue and sluggish tissue recovery, and CoQ10 helps improve their overall tissue resilience and comfort.